HIGHLIGHTS
- who: Georgios Kotsaris from the (UNIVERSITY) have published the paper: Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors, in the Journal: (JOURNAL)
- what: The authors show that Osr1 is required for FAP function during skeletal muscle regeneration. Osr1-deficient FAPs showed increased expression of Tgfb1, and the authors show that the myogenesis-inhibiting effect of Osr1cKO FAPs can be counteracted by blocking TGFu03b2 signaling with a receptor kinase inhibitor. The studies show that FAPs are key mediators of an intricate balance coordinating inflammation and regenerative myogenesis, and that Osr1 is . . .
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