Odf2l acts as synthetic lethal partner with wee1 inhibition in epithelial ovarian cancer models

HIGHLIGHTS

• who: Jie Li and collaborators from the Departmentsen University, Guangzhou, China have published the research work: ODF2L acts as synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models, in the Journal: (JOURNAL)
• what: The study provides evidence that ODF2L restores the G2/M checkpoint by mediating the recruitment of PKMYT1 to the CDK1 complex in EOC cells treated with a WEE1 inhibitor.
• how: The above results indicated that ODF2L knockdown promoted dysregulation of the cell cycle and further exacerbated DNA damage induced by WEE1 inhibition in EOC cells. To further validate . . .
  

   

  

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