Oestrogen receptor α af-1 and af-2 domains have cell population-specific functions in the mammary epithelium

HIGHLIGHTS

• who: Stéphanie Cagnet from the Institut Fédérale de Lausanne, Lausanne, SwitzerlandUniversity of have published the research: Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors explore the role of AF-1 and AF-2 vs. intact ERα signalling in mammary gland development; the authors demonstrate differential roles that are dependent on cell type and/or ERα protein levels and uncover important functions of the ERα in apparently ERα-luminal responder cells. Contrary to current . . .
  

   

  

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