Olaparib synergizes with arsenic trioxide by promoting apoptosis and ferroptosis in platinum-resistant ovarian cancer

HIGHLIGHTS

• who: Sangsang Tang from the Primary cell culture Tissue samples were collected from three patients diagnosed with highgrade serous OC at Women`s Hospital, Zhejiang University School of Medicine, ChinaThe study was approved by the Hospital Ethical Committee (approval no. IRB-20220229-R). The samples were surgically removed and immediately processed as the following steps. Briefly, tissue samples were cut into several small pieces on ice and then digested using a mix of collagenase I, IV and DNase I (Sigma). Next, digested samples were filtered with a, u03bcM cell strainer and then harvest the cells by centrifuging . . .
  

   

  

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