Oligomerization and conformational change turn monomeric -amyloid and tau proteins toxic: their role in alzheimer’s pathogenesis

HIGHLIGHTS

• who: Botond Penke and colleagues from the Department of Medical Chemistry, University of Szeged, Szeged, Hungary have published the research: Oligomerization and Conformational Change Turn Monomeric -Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis, in the Journal: Molecules 2020, 25, 1659 of /2020/
• what: In this review, the authors summarize the most important results of AD research, focusing on the physiological role, structure, and toxic effects of different Aβ peptide and tau protein assemblies.

SUMMARY

It has been accepted that brain accumulation of Aβ peptide and hyperphosphorylated tau . . .

 



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