Oligomerization of a g protein-coupled receptor in neurons controlled by its structural dynamics

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  • who: Thor C. Mamp#x000F8 and ller from the (UNIVERSITY) have published the Article: Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics, in the Journal: (JOURNAL) of 26/06/2018
  • what: Following the recent observation that mGlu receptors are in constant and rapid equilibrium between several states under basal conditions, the authors propose that this structural heterogeneity limits receptor oligomerization. This study shows that mGlu2 receptors are strict dimers under basal conditions when expressed in cultured hippocampal neurons at or near their endogenous levels as revealed using sN and . . .

     

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