On the role of a conserved methionine in the na+-coupling mechanism of a neurotransmitter transporter homolog

HIGHLIGHTS

  • who: Wenchang Zhou from the Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA have published the research work: On the Role of a Conserved Methionine in the Na+-Coupling Mechanism of a Neurotransmitter Transporter Homolog, in the Journal: (JOURNAL)
  • what: The authors examine the role of Met314 for the ­GltTk transporter through biochemical stoichiometry assays, molecular dynamics simulations, and quantum mechanical calculations.
  • how: To be able to calculate trajectories probing the microsecond timescale for such a system and thus derive statistically significant data the . . .

     

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