HIGHLIGHTS
- who: Simon Zinkhan et al. from the United States University of Western Australia have published the article: On the role of allergen-specific IgG subclasses for blocking human basophil activation, in the Journal: (JOURNAL)
- what: This has led to the general consensus in the field that induction of IgG4 is the major goal of specific immunotherapy. To investigate whether IgG4 was more potent than other IgG subclasses at blocking cellular activation, the authors focused on basophils as primary human mast cells are very difficult to obtain.
- how: IgG1 and IgG4 similarly neutralize allergen . . .
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