HIGHLIGHTS
- who: Federica Campolo et al. from the Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy have published the research work: Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers, in the Journal: (JOURNAL)
SUMMARY
Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are intracellular second_messengers that play a central role in a plethora of signaling pathways, involved in cell proliferation and differentiation, cell-cycle regulation, Ca2+ -dependent signaling, inflammation and metabolic function. PDEs share a common structural organization, with a conserved carboxyterminal catalytic domain, while amino . . .
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