Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma

HIGHLIGHTS

• who: Hidetoshi Sumimoto from the DepartmentShiga University have published the article: Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma, in the Journal: Scientific Reports Scientific Reports

SUMMARY

As several previous reports indicated that C ­ D8+ T_cell infiltration was reduced in EGFR-mt ­LA10,17,18, the authors tried to confirm this phenomenon. IHC of CD8a using surgical specimens confirmed that the number of C ­ D8a+ T_cells were significantly lower in EGFR-mt than EGFR-wt LA. This indicated that EGFR-mt LA was associated . . .

 



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