Oncogenic herpesvirus kshv triggers hallmarks of alternative lengthening of telomeres

HIGHLIGHTS

• who: Timothy P. Lippert from the Department University of have published the research: Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors investigate the impact of KSHV on telomeres in host cells in detail and find that infection triggers hallmarks of telomere elongation by homologous recombination (ALT) in initially non-ALT_cell lines. The authors show that intact ALT-associated BIR contributes to KSHV latency, which raise the possibility that KSHV induces ALT to co-opt the BIR machine for efficient viral functionality. The normal . . .
  

   

  

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