Oncolytic tanapoxvirus recombinants expressing flagellin c or mouse interleukin-2 are capable of regressing human triple-negative breast cancer xenografts in immuno-competent balb/c nude mice

HIGHLIGHTS

• What: In this study two (TPV) one FliC and the other mouse interleukin-2 (mIL-2) were assessed for their efficacy in an xenograft mouse model. A set of experiments was conducted to determine the presence of anti-TPV antibodies present in serum samples from mice treated with TPV and reconstituted with splenocytes. Similar to the challenges of the model in, MHC compatibility was a main obstacle to the establishment of grafts in systems with functional T-cell populations. The primary reason that an analysis of this kind was necessary was that a control variable (RC) and . . .
  

   

  

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