Oncosuppressive mirnas loaded in lipid nanoparticles potentiate targeted therapies in braf-mutant melanoma by inhibiting core escape pathways of resistance

HIGHLIGHTS

• who: Luigi Fattore from the (UNIVERSITY) have published the paper: Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance, in the Journal: (JOURNAL) of 23/Nov/2022
• what: The authors provide experimental evidence that the systemic delivery of LNPs carrying oncosuppressor miRNAs strongly potentiates the antitumor efficacy of MAPKi therapy and blunts the development of drug resistance in BRAFmutant melanoma xenografts. The authors provide compelling evidence that LNPs encapsulating selected oncosuppressor miRNAs such as miR204-5p and miR-199b-5p may be considered as . . .
  

   

  

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