“one ring to bind them all”—part ii: identification of promising g-quadruplex ligands by screening of cyclophane-type macrocycles

HIGHLIGHTS

• who: Anton Granzhan and colleagues from the Institut Curie, Centre Universitaire Paris XI, Bat110, Orsay, France have published the paper: “One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles, in the Journal: (JOURNAL) of 29/01/2010
• what: The authors show here that this class of macrocycles offers unique advantages for targeting G-quadruplex-DNA.
• how: This method also enables to gain insight into the quadruplex- over duplexDNA selectivity if the melting experiments are carried out in the presence of various amounts . . .
  

   

  

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