HIGHLIGHTS
- who: Diane Reckziegel and colleagues from the Duloxetine-induced changes in brain activation differ between responders and non-respondersDesign and methods This is a single-centre, double-blind, placebo-controlled mechanistic study being conducted at the University of Nottingham (UK). Inclusion criteria To participate in this study, individuals must have chronic knee pain with radiographically defined OA changes (Kellgren Lawrence grade , or higher), be able to consent to participation and be aged , or older. They must also be free of major medical, neurological and psychiatric comorbidities known to affect neural processing of pain. Exclusion criteria Potential candidates . . .
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