Opioids and their receptors: present and emerging concepts in opioid drug discovery ii

HIGHLIGHTS

• who: Richard M. Van Rijn and Mariana Spetea from the contradictoryThus, further studies will be welcome to provide better insight into possible interactions and whether they can be exploited therapeutically. Binienda et_al investigated but did not identify the presence of a synergistic interaction between the opioid receptor agonists and modulators of FFA receptors [32]. Specifically, the authors tested the u00b5OR agonist DAMGO with , antagonist GLPG-09734, agonist GSK, and , antagonist , in a mouse model of colitis. The , antagonist was also tested in the presence of the u03b4OR agonist DPDPE but also without a strong effect. Finally, Radoi . . .
  

   

  

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