HIGHLIGHTS
- who: Ilana Braunstein from the (UNIVERSITY) have published the research: Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation, in the Journal: (JOURNAL) of December/26,/2019
- what: The authors investigated the apoptosis-modulating effects of polysulfides, especially on the caspase cascade, which mediates the intrinsic apoptotic pathway. The authors show that the proenzymes procaspase-3 and -9 are basally persulfidated in resting (unstimulated) cells and become depersulfidated during their processing and activation.
- how: The results showed that a 30 min incubation with Trx/TrxR and NADPH resulted in near-complete . . .
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