HIGHLIGHTS
- who: Oleg Semenov et al. from the Nanosystems, Institute of Biomedical Chemistry, Moscow, Russia Sapporo Medical University, Japan have published the article: Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition, in the Journal: (JOURNAL)
SUMMARY
The p53 tumor suppressor protein plays the role of the "guardian of the genome" mediating the DNA damage response leading to cell cycle arrest, cellular senescence, and apoptosis (Lane, 1992). As a transcription factor, p53 binds the DNA cognate sites in the regulatory regions of its target genes, including non . . .
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