HIGHLIGHTS
- who: Irene G. Huber from the (UNIVERSITY) have published the research work: Opposite Effects of a Single IIIS5 Mutation on Phenylalkylamine and Dihydropyridine Interaction with L-type Ca2+ Channels*, in the Journal: (JOURNAL) of October/18,/2004
- what: The authors report that Tyr-1066 unexpectedly increased PAA affinity by stabilization of the PAA-channel complex. By demonstrating that a tyrosine residue in position 1066 increases PAA affinity, the authors provide novel insight into the organization of the LTCC multisubsite drug binding domain. The authors show that the bound PAA molecule is well within reach of . . .
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