Optical control of insulin release using a photoswitchable sulfonylurea

HIGHLIGHTS

• who: Johannes Broichhagen from the München, Germany, Division of Biosciences, Department of Neuroscience, Physiology and Pharmacology, University College London, London WC E BT have published the paper: Optical control of insulin release using a photoswitchable sulfonylurea, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 14/Oct/2014
• what: The authors demonstrate that JB253 offers sensitive, reversible and repeated manipulation of KATP channel state and beta cell activity with visible light, yielding optical control over insulin release. The authors aimed for a cyclohexyl substituent on the urea moiety that mimics the corresponding substituent on glimepiride . . .
  

   

  

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