Optimal combination of arsenic trioxide and copper ions to prevent autoimmunity in a murine hocl-induced model of systemic sclerosis

HIGHLIGHTS

• who: Charlotte Chu00eane from the STipe Therapeutics, Denmark University of Patras, Greece have published the Article: Optimal combination of arsenic trioxide and copper ions to prevent autoimmunity in a murine HOCl-induced model of systemic sclerosis, in the Journal: (JOURNAL)
• what: The authors evaluate here, in_vitro and in a mouse model of SSc, the improved efficacy of ATO when associated with a Fenton-like divalent cation, namely copper chloride (CuCl2), also known to trigger the production of ROS. The authors showed an increased expression of CCL-22 in the skin of HOCl-SSc mice compared . . .
  

   

  

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