HIGHLIGHTS
SUMMARY
Functional interaction networks connect genes which operate in the same biological process or pathway. In human cells, genome-scale pooled library knockdown or CRISPR-mediated gene knockout screens enabled the comparison of gene loss of function fitness vectors across cell lines, which show the same tendency toward co-functionality. After combining gRNA-level fold changes into gene-level scores, each published approach uses different sample-level variance normalization. Kim et_al use quantile normalization with no reference distribution, which resets the value of each gene to the mean of all gene fitness scores at that . . .
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