HIGHLIGHTS
- who: Tianshu Feng from the Oxford University UK have published the article: Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1, in the Journal: (JOURNAL) of February/20,/2014
- what: The authors show that Jmjd4 optimizes translational termination via lysyl hydroxylation of the stop codon recognition domain of an essential release_factor termed eRF1. Endogenous eRF1 K63 Hydroxylation Is Abundant, Ubiquitous, and Dependent on Jmjd4 Enzyme Activity Next, the authors aimed to characterize the hydroxylation of endogenous eRF1. The work describes the regulatory modification of a highly conserved region of eRF1 known to play an important . . .
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