HIGHLIGHTS
- who: Yujing Sun from the (UNIVERSITY) have published the research: Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology, in the Journal: (JOURNAL)
- how: The results showed that mutations of T1A and T12A enhanced p15 activity. By performing the alanine scanning of p15 which has been known to activate ADGRG2 the authors identified the key residues including F3 L6LDL9 and R11 that are important for p15-induced ADGRG2 activity.
SUMMARY
The authors next designed systematic strategies to optimize the peptide agonist of . . .
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