Optimization of peptide linker-based fluorescent ligands for the histamine h1 receptor

HIGHLIGHTS

  • who: Zhi Yuan Kok and colleagues from the Zhi Yuan Kok, Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, University of Nottingham Biodiscovery Institute, University Park, Nottingham , RD, UK. have published the paper: Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor, in the Journal: (JOURNAL) of January/23,/2022
  • what: The authors report a series of high-affinity H1R fluorescent ligands varying in peptide linker composition orthosteric targeting moiety and fluorophore. During the study, the required N-Fmoc-3-azido-D-alanine, which was intended for use in the . . .

     

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