Optimization of the capsid of recombinant adeno- associated virus 2 (aav2) vectors: the final threshold?

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  • who: George V. Aslanidi et al. from the Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, United States of America, Powell have published the Article: Optimization of the Capsid of Recombinant Adeno- Associated Virus 2 (AAV2) Vectors: The Final Threshold?, in the Journal: PLOS ONE | www.plosone.org of March/19,/2013
  • what: In this study site-directed mutagenesis of each of the 17 surface-exposed threonine (T) residues was conducted and the transduction efficiency of four of these mutants T455V T491V T550V and T659V was . . .

     

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