Optimized rhombic experimental dynamic checkerboard designs to elucidate pharmacodynamic drug interactions of antibiotics

HIGHLIGHTS

  • who: Niklas Kroemer from the Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Hamburg, Germany have published the research: Optimized Rhombic Experimental Dynamic Checkerboard Designs to Elucidate Pharmacodynamic Drug Interactions of Antibiotics, in the Journal: (JOURNAL)
  • what: This study provides optimized experimental rhombic checkerboard designs to enable an efficient interaction screening with significantly reduced experimental workload. The aim of this study was to further optimize and reduce the design of Chen et_al . The model described the effect (E) as a function of the drug concentration (C) with the maximum effect (Emax), drug potency . . .

     

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