HIGHLIGHTS
SUMMARY
Acute lymphoblastic leukemia (ALL) is a heterogeneous malignancy in terms of clinical manifestations, biological background, clinical course, and prognosis. It affects the early stages of hematopoiesis and more frequently the B cell lineage (75-80% in adults and 85-90% in pediatric patients) than the T_cell lineage (20-25% in adults and 10-15% in pediatric patients). IG/TR Gene Rearrangements Clonal rearrangements of IG/TR genes can be detected in >95% of ALL patients and are the most frequently used markers for MRD analysis. In the case of the neoplastic transformation of a . . .
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