Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots

HIGHLIGHTS

  • who: Gracy and colleagues from the (UNIVERSITY) have published the article: Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots, in the Journal: (JOURNAL) of 28/Oct/2010
  • what: This work explores different directions for a systematic homology modeling of a diverse family of protein sequences. The models were also evaluated using free_energy calculations based on molecular mechanics and empirical solvation energies using the MM_GBSA script from the Amber suite . It is difficult to interpret the reason of this model degradation. The accuracy of the models were still degraded using the . . .

     

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