HIGHLIGHTS
- who: . et al. from the Iran University of Medical Sciences, Iran have published the research work: Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration, in the Journal: (JOURNAL)
- what: This study shows that H2O2 contributes to the progression of disc degeneration by impairing mitochondrial function, inhibiting mitophagy and promoting NPCs senescence and the disruption of matrix homeostasis. The study showed that OPTN overexpression significantly enhanced mitophagy in H2O2-treated NPCs, whereas mitophagy was significantly inhibited by the addition of CsA. The authors found that Parkin and PINK1 levels and the LC3II . . .
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