Optogenetic control of notch1 signaling

HIGHLIGHTS

• who: Joanna Kau0142afut from the (UNIVERSITY) have published the Article: Optogenetic control of NOTCH1 signaling, in the Journal: (JOURNAL)
• what: The authors show that an engineered OptoNotch (oN) system can regulate NOTCH1 activity with spatiotemporal precision. This experiment had 2 purposes: first, to determine whether optoNotch still targets the same genes as the native N1ICD, and second that its activation is reversible without further photo-activation. The authors report that NOTCH1 activity is indeed involved in cell proliferation and drug resistance in breast cancers, both estrogen-depended and TNBC.
• how: All data were . . .
  

   

  

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