Orai calcium channels: regulation, function, pharmacology, and therapeutic targets

HIGHLIGHTS

  • who: Hussein N. Rubaiy from the Department of Laboratory Medicine, Division of Clinical, Karolinska Institute and Karolinska have published the research work: ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets, in the Journal: Pharmaceuticals 2023, 16, 162. of /2023/
  • what: A spike in cytosolic calcium concentration regulates biological responses ranging from sperm motility and egg fertilization to cell death via apoptosis and necrosis.
  • future: Studies are needed to determine if an imbalance of other ions could be a factor to the development of Stormorken syndrome and TAM . Analogues of SKF-96365 have . . .

     

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