Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine vegf-a under hypoxia

HIGHLIGHTS

• who: Taichi Kashiwagi from the Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, u20118402, Japan have published the Article: Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia, in the Journal: (JOURNAL)
• what: The authors show that neurosphere formation of embryonic NSPCs is dramatically increased under hypoxia compared to normoxia. The authors show that NSPCs secret VEGF-A in an autocrine fashion to efficiently maintain themselves under hypoxic developmental environment. The authors focused on VEGF as a candidate to maintain NSPCs since the Vegf gene . . .
  

   

  

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