Orphan g protein-coupled receptor, gpr41, induces apoptosis via a p53/bax pathway during ischemic hypoxia and reoxygenation*

HIGHLIGHTS

• who: Masayasu Kimura from the reperfusion (62, ) because cardiomyocytes are terminally differentiated and cannot proliferateDespite convincing evidence that apoptosis occurs in cardiomyocytes during ischemia and reperfusion, the mechanism and signaling pathway that lead to apoptotic cell death have been poorly elucidated to date. We have described a novel receptor of apoptosis during reoxygenation after ischemic hypoxia, and it is possible that the inhibition of HIA-R could lead to the maintenance of cardiac function following coronary artery occlusion. Further studies are required to elucidate the role of HIA-R after ischemic hypoxia. Acknowledgments-We thank S. Fukuzawa . . .
  

   

  

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