Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting cd8+ t cells

HIGHLIGHTS

• who: Jesus Corria-Osorio from the (UNIVERSITY) have published the research: Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells, in the Journal: (JOURNAL) of 28/03/2022
• what: The work provides evidence that orthogonal gene engineering of T_cells to secrete an interleukin (IL)-2 variant binding tu00adhe IL-2Ru03b2u03b3 receptor and the alarmin IL-33 reprogrammed au00addou00adptu00adivu00adely tu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adru00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adau00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adu00adnu00adu00adu00adu00adu00adu00adu00adsu00adu00adu00adu00adu00adu00adfu00adu00adeu00adrred Tu00adu00adu00ad cells to acquire a novel, synthetic effector state, which deviated from canonical exhaustion and displayed superior effector functions. The authors provide evidence that orthogonal combinatorial T-cell . . .
  

   

  

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