Osteocalcin ameliorates cognitive dysfunctions in a mouse model of alzheimer’s disease by reducing amyloid β burden and upregulating glycolysis in neuroglia

HIGHLIGHTS

• who: Chang Shan from the Animals All animal experiments in this study were approved by the ethics committee of Shanghai Jiao Tong University (SJTU) and conducted according to the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals (NIH Publications No8023, revised, )., month-old B, Tg (APPswePSEN1dE9), Nju male mice were purchased from Nanjing University-Nanjing Institute of Biomedicine (Nanjing, China) and used as the AD mice model in this study, which express both the mutant human presenilin , (PS1-dE9) and human mouse amyloid preprotein (APPswe) fusion. Wild-type (WT) male littermates were . . .
  

   

  

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