HIGHLIGHTS
- who: Caroline Diener from the Institute of Human, University, Homburg, Germany have published the Article: Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites, in the Journal: (JOURNAL)
- what: Our data show cooperative scenarios for miRNAs that bind within the same endogenous 3u2032UTR of a target gene.
- how: For miR-21-5p and miR155-5p two commonly investigated regulators across diseases the authors selected 15 joint target genes. The authors examined cooperative miRNA effects on endogenous protein levels using the abovementioned pSG5-based miRNA expression system in 293T human embryonic . . .
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