Ovarian cancer cells in ascites form aggregates that display a hybrid epithelial-mesenchymal phenotype and allows survival and proliferation of metastasizing cells

HIGHLIGHTS

  • who: Sonia Capellero and colleagues from the Department of Oncology, University of Torino, Torino, Italy have published the research work: Ovarian Cancer Cells in Ascites Form Aggregates That Display a Hybrid Epithelial-Mesenchymal Phenotype and Allows Survival and Proliferation of Metastasizing Cells, in the Journal: (JOURNAL)
  • what: The aim of this work is to uncover the features make these the metastasizing units. Using cancer cell lines the authors show cells forming 3D structures neo-expressed thoroughly fibronectin and Functional assays showed and fibronectin are necessary for the compaction and survival of 3D structures. The authors . . .

     

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