Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

HIGHLIGHTS

• who: Gaëlle Marteil from the CentroUniversidade Pasteur de Montevideo, Montevideo, Uruguay have published the article: Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that overly long centrioles form over-active centrosomes that nucleate more microtubules a known cause of invasiveness and perturb chromosome segregation. The authors develop a pipeline to semiautomatically measure centriole number and length in mitotic cells. The authors focused initially in understanding the role of p53 and ploidy deregulation, given existing controversy on their importance23,60 . . .
  

   

  

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