Over-expression of plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

HIGHLIGHTS

• who: David M. Glover and colleagues from the Department of Genetics, University of Cambridge, Downing Street, Cambridge , EH, UK have published the research: Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse, in the Journal: (JOURNAL) of 02/Oct/2022
• what: The authors focus upon characterizing defects in the skin of these animals and show that elevated Plk4 leads to amplification of centrosomes and loss of primary cilia. The authors discuss how these phenotypes can arise and how the authors might account for the enhancement of . . .
  

   

  

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