Overcoming therapeutic resistance to platinum-based drugs by targeting epithelial–mesenchymal transition

HIGHLIGHTS

  • who: Xirui Duan from the Rudjer Boskovic Institute, Croatia India Fujian University of Traditional Chinese have published the research: Overcoming therapeutic resistance to platinum-based drugs by targeting Epithelialu2013Mesenchymal transition, in the Journal: (JOURNAL)
  • what: Despite the prospective effect, resistance to PBDs has become the main reason for chemotherapy failure in clinical treatments. In this review, the authors attempt to synthetically illustrate the underlying mechanism of EMT-induced resistance to metallodrugs.
  • how: Analysis of clinical data showed that most cancer rarely undergoes adequate transformation .

SUMMARY

    Cancer stem_cells (CSCs), a . . .

     

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