Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice

HIGHLIGHTS

• who: Tao Li from the The AIF overexpression transgenic mouse (AIF-Tgflox/flox) was constructed in a, /Bl, background using Rosa, locus gene targeting, and AIF overexpression was regulated by Cre recombinaseThe floxed mice were crossed with beta-actin-cre mice. The AIF-Tgflox/+-actin-cre (AIF overexpression, AIF Tg) and AIF-Tg+/+-actin-cre (wild type, WT) mice with reasonable body weight (4.0-5., g) at , and each litter with, pups were used in this study. A total of , pups were excluded because of death during surgery or during hypoxia, and a total of , mouse . . .
  

   

  

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