Overexpression of claspin and timeless protects cancer cells from replication stress in a checkpoint-independent manner

HIGHLIGHTS

• who: Julien N. Bianco from the CNRS University of Sabatier, Toulouse, France, Gustave Roussy Cancer Campus, Villejuif, France. have published the Article: Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that this depletion reduces fork speed, increases fork stalling and leads to accumulation of γH2AX, in a checkpoint-independent manner. In any case, the authors report here that the reduction of Claspin and Timeless levels in cancer cell lines reduced the speed of fork progression, increased . . .
  

   

  

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