Overexpression of cyclin e1 or cdc25a leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

HIGHLIGHTS

• who: Yannick P. Kok from the (UNIVERSITY) have published the paper: Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors, in the Journal: (JOURNAL)
• what: The authors aimed to uncover the consequences of Cyclin E1 or Cdc25A overexpression on replication kinetics mitotic progression and the sensitivity to inhibitors of the WEE1 and ATR replication checkpoint kinases. The authors assessed whether oncogene-induced replication stress as a result of Cyclin E1 or Cdc25A overexpression affects mitotic behavior of tumor cells and genome instability. Interestingly, the study . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.