Overexpression of pathogenic tau in astrocytes causes a reduction in aqp4 and glt1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild tbi without appreciable changes in tauopathy

HIGHLIGHTS

• What: Methods and materials Animals This study investigated three-month-old male and female C57BL/6 mice (n=12), ­GFAPP301L (n=12), and CaMKIIαP301L (n=12). Differential gene_expression analysis was conducted to determine relationships between gene_expression levels in the injury group versus their sham counterparts (DESeq2). Limitations of the study Data provides insights into the effects of overexpression of pathogenic tau in astrocytes under normal conditions and after r-mTBI, however, this study has several limitations. The authors demonstrate r-mTBI did not significantly exacerbate tau astrogliopathy, but increased tau phosphorylation in the cortical neurons beneath . . .
  

   

  

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