Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma

HIGHLIGHTS

SUMMARY

    Multiple kinds of immune checkpoint gene_expression profiles were investigated. Immunological characteristics of immunomodulators, cancer immunity cycle, and immune checkpoint gene_expression associated with the OAG score were also compared between the high and low OAG score groups. (D) Comparison of immunomodulator-related gene_expression between high and low OAG score groups. (G) Correlation between OAG score and immune inhibitory checkpoint gene_expression. Dysregulation of hepatic metabolisms, such as oxidative_phosphorylation, glycolysis, and fatty_acid metabolism, was critical to the development and progression of liver disease, especially in patients with non-alcoholic hepatitis disease. Similarly, GO and KEGG pathway enrichment . . .

     

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