HIGHLIGHTS
SUMMARY
This signal cascade plays central roles in GCs for LH/hCG-triggered ovulation by initiating oocyte meiosis resumption, inducing cumulus cell expansion, and triggering 100-fold increases in the mRNA expression of many ovulatory genes, such as Areg, Ereg, Sult1e1, and Star. The authors previously observed that epigenetic remodeling exists in LH/hCG-induced ovulation to facilitate the active transcription of substantial genes. Although KATs and HDACs are both located at the transcribed regions of active genes, HDACs are believed to remove acetyl groups at active genes and repress gene_expression. LH/hCG promotes activation . . .
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