HIGHLIGHTS
- who: Bernadette Carroll and collaborators from the Institute Newcastle University Vitality, Newcastle upon Tyne, PL, UK have published the paper: Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors demonstrate that in vertebrates, p62 senses the saturation of reactive oxygen species (ROS)-buffering systems, and that this redox-sensitivity is important to increase autophagy, and thus ensure the survival of cells under oxidative stress conditions. Instead, the authors propose a putative model of DLC formation involving a parallel orientation of p62 . . .
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