Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin-p53 interaction

HIGHLIGHTS

  • who: Yaoxian Xiang from the Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, Peopleu2019s Republic of China have published the Article: Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin-p53 interaction, in the Journal: (JOURNAL)
  • what: The authors examine the expression of p53 and progerin and their interactions in the denervated muscles. The authors show that denervation induces an increase in ROS and iNOS-derived NO, which lead to the upregulation of progerin and p53.
  • how: The cells were then examined by flow cytometry and the . . .

     

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