Oxidized hemoglobin triggers polyreactivity and autoreactivity of human igg via transfer of heme

HIGHLIGHTS

• who: Cyril Planchais from the Institut have published the research: Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme, in the Journal: (JOURNAL) of 11/07/2022
• what: The authors investigated the functional impact of Hb on human immunoglobulins. The authors demonstrate that incubation of polyclonal or some monoclonal human IgG antibodies in the presence of oxidized hemoglobin (methemoglobin) resulted in an appearance of polyreactivity and reactivity towards distinct self-proteins. Discussion Here the authors show that human antibodies acquire polyreactivity and autoreactivity after incubation with sub-equimolar concentrations of oxidized . . .
  

   

  

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